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目的：探讨临床肾移植术后肝脏损害的病因及其诊断和治疗原则。方法：收集１９８０年１月～１９９６年５月间所作肾移植患者中发生肝脏损害的病例２０５例４１９例次，按发病原因进行分类，并分析各种原因引起的肝脏损害的特点、治疗方法及转归。结果：药物性肝脏损害占５３．７０％，病毒性肝炎占２７．６６％，其它原因引起者占７．６４％，原因不清楚者占１０．９８％。治疗后痊愈７５．６１％，未愈１５．１２％，死亡９．２７％。结论：免疫抑制药物的肝毒性及病毒性肝炎是肾移植术后肝脏损害的主要原因，在临床上各有其特点，并介绍了作者对早期肝脏损害的治疗经验
Objective: To investigate the etiology and diagnosis and treatment of liver damage after renal transplantation. Methods: A total of 419 cases of liver damage in renal transplant patients from January 1980 to May 1996 were collected, classified according to the cause of the disease and analyzed the characteristics of liver damage caused by various causes, treatment methods and Go. Results: Drug-induced liver damage accounted for 53.70%, viral hepatitis accounted for 27.66%, caused by other causes accounted for 7.64%, unexplained accounted for 10.98%. After treatment, healed 75.61%, healed 15.12% and died 9.27%. Conclusions: The hepatotoxicity and viral hepatitis of immunosuppressive drugs are the main causes of liver damage after kidney transplantation. They have their own characteristics in clinic and the author’s experience in the treatment of early liver damage