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虽然麻黄鹼早在1885年已从麻黄草中分出,并且在1920年已经人工合成,但是麻黄鹼的含量测定,迄今仍缺乏满意的方法。考查文献上所见的麻黄鹼的含量测定法,主要可归纳为二大类,就是酸鹼滴定法和比色法。中华人民共和国药典(中国药典)的方法所根据的原理是先用鹼使样品(麻黄鹼鹽类的纯品或麻黄流浸膏)中的麻黄鹼游离,继用醚抽出,然后采用酸鹼滴定。英国药典和美国药典的含量测定法也如上述。这法的缺点是:(1)用醚和酸液反复抽取,手续麻
Although ephedrine was segregated from Ephedra as early as 1885 and had been artificially synthesized in 1920, the content of ephedrine was still not satisfactory. Examination of the ephedrine content found in the literature can be mainly classified into two major categories, namely acid-base titration and colorimetry. The method of the Chinese Pharmacopoeia (Chinese Pharmacopoeia) is based on the principle that the ephedrine in the sample (ephedrine salt or ephedra extract) is first freed with alkali, followed by extraction with ether, and acid-base titration is then used. . The British Pharmacopoeia and United States Pharmacopoeia assays are also as described above. The disadvantages of this method are: (1) repeated extraction with ether and acid, procedures