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目的 探讨三氧化二砷（Ａｓ２Ｏ３）与联合化疗序贯治疗急性早幼粒细胞白血病（ＡＰＬ）的疗效与副作用。方法 首先对３ 例初治病人与４例复发病人分别给予全反式维甲酸（ＡＴＲＡ）和（Ａｓ２Ｏ３ ）以诱导缓解，完全缓解（ＣＲ）后用ＤＡ、ＨＡ方案与Ａｓ２Ｏ３ 序贯治序。结果 ７ 例病人均获ＣＲ，目前仍保持ＣＲ状态，持续ＣＲ的时间已１０个～４４个月。结论 Ａｓ２Ｏ３ 与联合化疗序贯治疗ＡＰＬ具有疗效好，毒副作用轻，易于长期维持治疗等优点。
Objective To investigate the efficacy and side effects of arsenic trioxide (As2O3) and sequential chemotherapy in the treatment of acute promyelocytic leukemia (APL). Methods First of all, 3 cases of untreated patients and 4 cases of relapsed patients were treated with all-trans retinoic acid (ATRA) and (As2O3) to induce remission. After complete remission (CR), DA, HA regimen and As2O3 sequential treatment were used. Results CR was obtained in all 7 patients and CR status was maintained. The duration of CR was 10 to 44 months. Conclusions As2O3 combined with sequential chemotherapy has a good curative effect on APL, with low toxic and side effects, and it is easy to maintain long-term treatment.