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目的探讨研究伽玛刀联合DC-CIK细胞治疗对肝癌患者生活质量的影响。方法选择2012年1月-2014年1月收治的肝癌患者50例,按治疗方法不同分为单纯组与联合组各25例,单纯组在伽玛刀治疗的同时接受相应的放疗治疗,联合组在伽玛刀治疗的同时进行DC-CIK细胞免疫治疗。观察2组治疗方法对患者生活质量的影响。结果联合组治疗后社会功能、心理功能及躯体功能评分明显高于单纯组,差异有统计学意义(P<0.05),2组物质生活评分比较差异无统计学意义(P>0.05)。单纯组治疗1个月后出现食欲下降1例,精神状态差2例,睡眠质量下降2例,全身疲软无力1例,伴随疼痛5例;联合组治疗1个月后所有患者进食量正常,精神状态良好,仅1例睡眠质量较差,无疲乏感,2例伴中轻度疼痛,2组不良反应比较差异有统计学意义(P<0.05)。结论伽玛刀和DCCIK细胞免疫技术联合应用治疗肿瘤生长中有协同作用,提高机体免疫力,改善患者临床症状,提高患者生活质量。
Objective To investigate the effect of gamma knife combined with DC-CIK cell therapy on the quality of life of patients with liver cancer. Methods From January 2012 to January 2014, 50 patients with hepatocellular carcinoma who were admitted to our hospital from January 2012 to January 2014 were divided into two groups according to different treatment methods: 25 patients in the simple group and the combined group, while the patients in the simple group received the corresponding radiotherapy while the gamma knife was treated. DC-CIK cellular immunotherapy was performed at the same time as gamma knife treatment. The effects of two treatment methods on the quality of life of the patients were observed. Results The scores of social function, psychological function and physical function in the combined group were significantly higher than those in the simple group (P <0.05). There was no significant difference in the material life scores between the two groups (P> 0.05). One month after treatment, appetite decreased in 1 case, mental state in 2 cases, sleep quality decreased in 2 cases, general weakness and weakness in 1 case, accompanied by pain in 5 cases; the combination group after 1 month, all patients with normal food intake, the spirit Only 1 patient had poor sleep quality and no fatigue, 2 patients had moderate pain, and 2 adverse reactions were statistically significant (P <0.05). Conclusion The combined application of gamma knife and DCCIK cellular immunotherapy has a synergistic effect in the treatment of tumor growth, enhances immunity, improves clinical symptoms and improves quality of life of patients.