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为探讨日本血吸虫虫卵肉芽肿形成机理和病理作用，本实验改进Ｂｏｔｒｏｓ方法，设虫卵可溶性抗原（ＳＥＡ）致敏组和未致敏组，选用Ｃ５７ＢＬ／６鼠经脾注射虫卵诱发小鼠日本血吸虫肝肉芽肿，并对虫卵诱发的细胞反应进行了观察。结果显示：（１）经脾注射虫卵诱发小鼠肝肉芽肿方法简单、安全、有效；所建模型，特别是致敏组模型在肉芽肿形成机理研究中较有价值。（２）ＳＥＡ致敏可加强日本血吸虫肝肉芽肿形成．（３）抗体或抗原－抗体复合物作用参与日本血吸虫肝肉芽肿形成。（４）虫卵及虫卵肉芽肿均对肝细胞具有一定损伤作用。
In order to investigate the mechanism of formation and pathological effects of Schistosoma japonicum egg granuloma, the experiment improved Botros method, set the sensitized group of SEA and sensitized group, selected C57BL / 6 mice by spleen injection of eggs to induce mice Schistosoma japonicum liver granuloma, and egg-induced cellular responses were observed. The results showed that: (1) The method of spleen injection of mouse eggs to induce liver granuloma in mice is simple, safe and effective. The model, especially the sensitized group, is more valuable in the study of the mechanism of granuloma formation. (2) SEA sensitization can enhance the formation of Schistosoma japonicum liver granuloma. (3) Antibody or antigen-antibody complex involved in the formation of Schistosoma japonicum liver granuloma. (4) The eggs and granuloma of the eggs have certain damage to the liver cells.