,Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female

• 作 者: Yi-hua SUN Rong FANG Bin GAO Xiang-kun HAN Jun-hua ZHANG William PAO Hai-quan CHEN Hong-bin JI
• 机 构: Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute
• 出 处: 中国药理学报（英文版）
• 发表日期: 2010年5期

Lung cancer patients with the epidermal growth factor receptor (EGFR) kinase domain mutations frequently show good responses to small molecule tyrosine kinase inhibitors, including Iressa and Tarceva, in clinical studies[1-3]. Previous studies have demonstrated that EGFR kinase domain mutations are commonly observed in lung adenocarcinomas, never-smokers,East Asian, and females[4-8].