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目的:探讨急性缺血性脑卒中(AIS)患者血浆蛋白Z(PZ)水平变化及临床意义。方法:采用病例-对照的研究方法,随机选取88例缺血性脑卒中患者及同期84例健康体检者。AIS患者均为急性期(发病后1-3d)取静脉血。以酶联免疫吸附法(ELISA)检测各组中血浆中PZ的含量。根据头部核磁共振(MRI)结果将AIS患者分为两组:皮质动脉卒中组和穿通动脉卒中组。结果:急性缺血性脑卒中患者血浆PZ水平明显高于健康对照组(P<0.01)。穿通动脉卒中组血浆PZ水平明显低于皮质动脉卒中组(P<0.05),而与健康对照组差异无显著性(P>0.05)。结论:血浆PZ水平明显增高是缺血性脑卒中的危险因素,提示血浆PZ水平增高可能在皮质动脉卒中发病中起到一定的作用。
Objective: To investigate the change of plasma protein Z (PZ) level in patients with acute ischemic stroke (AIS) and its clinical significance. Methods: A case-control study was conducted in which 88 patients with ischemic stroke and 84 healthy subjects were selected at random. AIS patients are acute (1-3d after onset) to take venous blood. Plasma PZ levels in each group were detected by enzyme-linked immunosorbent assay (ELISA). Patients with AIS were divided into two groups based on head MRI results: cortical arterial stroke group and perforating arterial stroke group. Results: Plasma PZ level in acute ischemic stroke patients was significantly higher than that in healthy controls (P <0.01). Plasma PZ level in stroke group was significantly lower than that in cortical artery stroke group (P <0.05), but not significantly different from healthy control group (P> 0.05). Conclusion: Plasma PZ levels are significantly increased risk factors for ischemic stroke, suggesting that increased plasma PZ levels may play a role in the incidence of cortical arterial stroke.