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作者报导2例癫痫患者应用丙戊酸钠(VPA)治疗而引起酮病和肉碱不足的昏迷.例1,女,29岁,患复杂部分性癫痫,每日酰胺咪嗪(CBZ)1600mg,因癫痫延长发作而住院.患者有偏头痛、行为异常和妊娠剧吐史.静注葡萄糖和加用每日VPA2000mg(32mg/kg)后,翌日诉恶心、呕吐和烦躁不安.3天后昏迷.动脉血含氧量为28%,pH值7.51,Paco_219mmHg,Pao_2ll6mmHg.静脉血二氧化碳容量15mmol/L.VPA血浓度60μg/ml
The authors report two cohorts of epilepsy patients treated with valproate (VPA), which caused ketosis and carnitine deficiency.Example 1. Female, 29 years old with complex partial epilepsy, daily carbamimidine (CBZ) 1600 mg, Hospitalized for prolonged epileptic seizures, patients with migraines, abnormal behavior, and history of exacerbation of pregnancy.Vaginal nausea, vomiting, and restlessness the following day after coadministration of glucose and with daily VPA 2000 mg (32 mg / kg) were coma after 3 days. Blood oxygen content of 28%, pH 7.51, Paco_219mmHg, Pao_2116mmHg. Venous carbon dioxide capacity of 15mmol / L. VPA blood concentration of 60μg / ml