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肿瘤化学治疗开始于40年代烷化剂的应用,1950年许多抗代谢药和激素相继用于临床,至1960年抗肿瘤药物逐渐增多,治疗某些恶性肿瘤取得了暂时性缓解。近几年的进展颇为迅速,如对急性白血病的治疗,无论是缓解率、缓解期、长期生存率或杀细胞率,都有很大提高,可在少数患者中达到治愈。药物治疗已得到广泛的重视,可与手术和放射冶疗并列,成为治疗恶性肿瘤不可缺少的手段。但是我们也应看到,目前的化疗水平与根治的要求还有相当距离,对实体瘤的治疗还不理想,药物的毒性问题、选择性问题、缓解期短的问题,特
Cancer chemotherapy began in the 1940s with the use of alkylating agents. In 1950, many antimetabolites and hormones were successively used in clinical practice. By 1960, anti-cancer drugs had gradually increased, and some malignant tumors had been temporarily relieved. Progress in recent years has been quite rapid. For example, the treatment of acute leukemia, whether it is remission rate, remission period, long-term survival rate or cell kill rate, has greatly improved and can be cured in a small number of patients. Drug treatment has received extensive attention and can be tied with surgery and radiation therapy, and has become an indispensable means for the treatment of malignant tumors. However, we should also see that the current level of chemotherapy is still quite a distance from the requirements of radical treatment. The treatment of solid tumors is not yet satisfactory. The toxicity of drugs, the problem of selectivity, and the problem of short remission periods are particularly limited.