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目的 探讨环境因素对儿童白血病的影响 ,了解儿童白血病的可能危险因素。方法 采用病例-对照研究的方法 ,在FoxPro 6 0中建立数据库 ,运用SPSS 10 0进行统计分析处理。结果 单因素分析结果显示 ,家族遗传病史、X射线照射史、近 1年内感冒史、出生时的胎次 (第 1胎与第 2胎及以上 )、鱼肝油服用史、居室装修史、居室与高压电线的距离均与儿童白血病有关。多元非条件Logistic回归分析表明 ,除鱼肝油服用史 (比值比OR =0 3,95 %的可信区间CI =0 2～ 0 7)外 ,家族遗传病史 (OR =4 4 ,95 %CI =1 2～ 16 5 )、X线照射史 (OR =3 2 ,95 %CI =1 6～ 6 1)、近 1年内感冒史 (OR =2 6 ,95 %CI =1 2～ 5 5 )和居室装修史 (OR =2 0 ,95 %CI=1 0～ 3 9)是儿童白血病的重要危险因素。其中 ,居室装修史与儿童白血病之间的关系是首次报道 ,而服用鱼肝油具有保护作用。结论 家族遗传病史、X射线照射史、近 1年内感冒史和居室装修史是儿童白血病的重要危险因素。
Objective To investigate the impact of environmental factors on childhood leukemia and to understand the possible risk factors of childhood leukemia. Methods A case-control study was conducted to establish a database in FoxPro 6.0 and to perform statistical analysis using SPSS 10 0. Results The results of univariate analysis showed that the family history of genetic disease, history of X-ray irradiation, history of cold during the past year, birth parity (first and second births and above), history of taking cod liver oil, history of room decoration, The distance between wires is related to childhood leukemia. Multivariate non-conditional logistic regression analysis showed that family history of genetic disease (OR = 44, 95% CI = 1) was significantly higher than that of cod liver oil use except for the use of cod liver oil (odds ratio OR = 0, 95% confidence interval CI = 2-16 5), history of X-ray irradiation (OR = 3.2, 95% CI = 16-6 1), history of cold in the past year (OR = 26.55% CI = 12.5-2.5) The history of decoration (OR = 20, 95% CI = 10 ~ 39) was an important risk factor for childhood leukemia. Among them, the relationship between the history of room decoration and childhood leukemia is the first report, while taking cod liver oil has a protective effect. Conclusion The family history of hereditary diseases, the history of X-ray radiation, the history of cold and the history of room decoration in the past year are important risk factors for childhood leukemia.