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目的观察德巴金对卒中后顽固性呃逆的疗效。方法58例卒中后顽固性呃逆病人分为2组,其中治疗组21例(男性19例,女性2例,年龄65±7岁)采用德巴金治疗。最小剂量是0.5,Bid。最大剂量为1.0,Bid。小剂量开始,逐步递增,疗程4 d。37例对照组(男性30例,女性7例,年龄67±10岁)采用脊舒、胃复安、654-2、氯丙嗪、吗丁啉、硝苯地平、中药、针灸等常规方法治疗。结果治疗组总有效率95.2%,对照组总有效率83.8%,两组之间的差别无统计学意义(P>0.05),但治疗组的治愈率85.7%,对照组的治愈率54.1%,两者之间有显著差别(P<0.05)。治疗组服药1天起效率81%,对照组服药1天起效率12%(P<0.05),治疗组疗程明显缩短(P<0.01),无不良反应。结论德巴金是治疗卒中后顽固性呃逆较为安全有效的药物。
Objective To observe the effect of Debarkin on intractable hiccups after stroke. Methods Fifty-eight patients with refractory hiccup after stroke were divided into two groups. Among them, 21 patients in the treatment group (19 males and 2 females, age 65 ± 7 years) were treated with dexamethasone. The minimum dose is 0.5, Bid. The maximum dose is 1.0, Bid. Small dose began, gradually increasing, treatment 4 d. 37 cases of control group (30 males and 7 females, age 67 ± 10 years) were treated by routine methods of spinal, meperidine, 654-2, chlorpromazine, domperidone, nifedipine, traditional Chinese medicine and acupuncture . Results The total effective rate was 95.2% in the treatment group and 83.8% in the control group. There was no significant difference between the two groups (P> 0.05), but the cure rate was 85.7% in the treatment group and 54.1% in the control group, There was a significant difference between the two (P <0.05). The effective rate of treatment group was 81% from day 1, while that of control group was 12% (P <0.05). The course of treatment in treatment group was significantly shortened (P <0.01) and no adverse reactions were observed. Conclusion DBT is a safe and effective treatment for intractable hiccups after stroke.