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目的:观察脑心通加阿司匹林预防心房颤动患者脑栓塞的效果和不良反应。方法:选择冠状动脉粥样硬化性心脏病心房颤动101例,随机分为观察组51例,对照组50例。两组在基础治疗前提下,对照组采用阿司匹林预防;观察组在服用阿司匹林的同时加用脑心通胶囊。两组均随访3年,以脑栓塞发生率判定效果。结果:观察组3年累计发生脑梗死6例(11.8%),对照组发生15例(30.0%),两组比较差异显著(P<0.05);观察组服药期间发生上腹部疼痛、恶心6例,头晕2例,对照组发生上腹部疼痛、恶心5例,两组比较差异不显著(P>0.05)。结论:脑心通加阿司匹林预防心房颤动患者脑栓塞效果优于单用阿司匹林,且比较安全。
Objective: To observe the effect and adverse reactions of Naoxintong plus aspirin in prevention of cerebral embolism in patients with atrial fibrillation. Methods: A total of 101 patients with atrial fibrillation of atherosclerotic heart disease were randomly divided into observation group (n = 51) and control group (n = 50). The two groups under the premise of basic treatment, the control group with aspirin prevention; observation group taking aspirin plus Naoxintong capsule. Both groups were followed up for 3 years to determine the effect of cerebral embolism. Results: In the observation group, cerebral infarction occurred in 6 cases (11.8%) in 3 years and 15 cases (30.0%) in the control group, with significant difference between the two groups (P <0.05). In the observation group, upper abdominal pain and nausea , Dizziness in 2 cases, control group occurred in upper abdominal pain, nausea in 5 cases, the difference between the two groups was not significant (P> 0.05). CONCLUSION: Naoxintong plus aspirin is superior to aspirin alone in preventing cerebral embolism in patients with atrial fibrillation, and is safe.