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目的探讨胃肠功能衰竭新生儿血清二胺氧化酶(DAO)和D-乳酸含量变化特点及其临床意义。方法19例胃肠功能衰竭新生儿为病例组,79例健康新生儿为对照组,测量两组新生儿血清DAO、D-乳酸含量。结果对照组血清DAO含量为(8.851±3.424)U/ml,血D-乳酸含量为(0.918±0.715)μg/ml。病例组血清DAO含量为(11.610±3.909)U/ml,D-乳酸含量为(1.859±0.972)μg/ml;病例组血清DAO、D-乳酸水平显著高于对照组(P<0.05,P<0.01)。不同疾病严重程度、不同胎龄、不同日龄患儿血清DAO、D-乳酸含量比较无显著性差异(P>0.05)。结论血清DAO和D-乳酸含量测定可作为新生儿胃肠功能衰竭早期诊断的敏感指标。
Objective To investigate the changes of serum diamine oxidase (DAO) and D-lactic acid content in neonates with gastrointestinal failure and its clinical significance. Methods Nineteen neonates with gastrointestinal failure were selected as the case group and 79 healthy neonates as the control group. Serum DAO and D-lactate levels were measured in two groups. Results In the control group, serum DAO level was (8.851 ± 3.424) U / ml and blood D-lactate level was (0.918 ± 0.715) μg / ml. Serum DAO level was (11.610 ± 3.909) U / ml and D-lactic acid level was (1.859 ± 0.972) μg / ml in the case group. Serum DAO and D-lactic acid levels were significantly higher in the case group than those in the control group (P < 0.01). There was no significant difference in serum DAO and D-lactic acid among children with different disease severity, different gestational age and different ages (P> 0.05). Conclusion Serum DAO and D-lactic acid levels can be used as sensitive indicators of early diagnosis of gastrointestinal failure in neonates.