Relationship between the imaging features and pathologic alteration in hepatoma of rats

• 作 者: Jia-He Yang Tian-Geng You Nan Li Qi-Jun Qian Ping Wang Zhen-Lin Yan Meng-Chao Wu
• 机 构: Eastern Heptobiliary Hospital, 225 Changhai Road, Shanghai 200433, China
• 出 处: 世界胃肠病学杂志(英文版)
• 发表日期: 2003年1期
• 关键词: primary liver cancer experimental model magnetic resonance imaging human liver l

AIM: The imaging features of MRI and DSA, using the modelsof implanted and induced hepatoma, were investigated in rats.METHODS: CBRH3 cancer cells were implanted for differentliver site of rat liver and the diethylnitrosoamine was givenorally to rats in order to induce liver cancer. Both experimentalgroups were detected by magnetic resonance imaging (MRI),digital subtraction angiography (DSA) and morphologic assay.RESULTS: Hypointensity on T1WI and homogenous highsignal intensity on T2WI in MRI, and ring-like abnormal stainon DSA were found in implanted cancer. Induced cancersappeared as homogeneous or heterogeneous hypointensityon T1WI (10 cases), and equal or slight high intensity onT2WI (8 cases), but some as hypointensity on T2WI (2 cases).CONCLUSION: The imaging features of implanted cancerswere similar to that of human liver metastases. Therefore, itcould serve as an experimental model of human liver metastatictumor. The imaging feature of induced cancers, whereas, weresimilar to that of human primary liver cancer. It could be useas an experimental model of human primary liver cancer.