Histological Grading in Ductal Carcinoma in Situ of the Breast

• 作 者: Xu Wei-ling Zhu Xiong-zeng Zhang Ting-qiu Tu Xiao-yu shi da-ren
• 机 构: Department of Pathology, Cancer Hospital, Shanghai Medical University, Shanghai 200032
• 出 处: 中国癌症研究（英文版）
• 发表日期: 2000年3期
• 关键词: Breast ductal carcinoma in situ Histology c-erbB-2 p53 MIB-1 estrogen receptor

Objective: To study the significance of histological grading as a prognostic factor in ductal carcinoma in situ of the breast. Methods: According to the Van Nuy’s classification, 32 cases of ductal carcinoma in situ (DCIS) of the breast were divided into three groups. Results: Low grade (well differentiated, low grade DCIS) 12 patients (37.5%); Intermediate grade, 9 patients (28.1%); High grade (poorly differentiated DCIS) 11 patients (34.4%). Among the high grade DCIS, the histologic subtypes were comedo (9 patients), micropapillary (1 patient) and solid (1 patient). The positive expression of c-erbB-2, p53 and MIB-1 in high grade DCIS was higher than that in intermediate and low grade DCIS. The difference between high grade and low grade DCIS was significant (p<0.05). The expression of ER in high grade DCIS was lower than that in intermediate and low grade DCIS. Conclusions: Histological grading of breast ductal carcinoma in situ may be a good prognostic factor.