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目的:探讨桃红四物汤对大鼠皮瓣移植后血管再生的作用机制。方法:将40只SD大鼠按随机排列表法分为A组(实验组)和B组(对照组),每组20只。制成8cm×3cm的背部随意皮瓣,A、B组分别予以桃红四物汤、生理盐水灌胃,于术后3d、7d两时相点,取吻合区皮片组织,免疫组化法染色光镜下观察bFGF及VEGF的含量。结果:术后3d、7d检测吻合区组织中bFGF及VEGF含量,A组各时相点均高于B组,两组差异有统计学意义(P<0.05)。结论:桃红四物汤可通过提高皮瓣组织中bFGF与VEGF含量,从而起到促进血管再生的作用。
Objective: To explore the mechanism of Taohong Siwu Decoction on the vascular remodeling after skin flap transplantation in rats. Methods: 40 SD rats were randomly divided into group A (experimental group) and group B (control group), with 20 rats in each group. Made 8cm × 3cm back of the random flap, A, B group were given Taohongsiwutang, saline gavage at 3d, 7d postoperative point, take the anastomosis of the skin tissue, immunohistochemical staining Light microscopy bFGF and VEGF content. Results: The contents of bFGF and VEGF in the anastomosis region were detected at 3d and 7d after operation. The time points in group A were higher than those in group B at each time point. There was significant difference between the two groups (P <0.05). Conclusion: Taohong Siwu decoction can promote the regeneration of blood vessels by increasing the contents of bFGF and VEGF in the skin flap.