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目的比较2型糖尿病患者合并急性冠状动脉综合征时应用两种不同胰岛素给药方法的治疗效果。方法将住院治疗的168例合并急性冠状动脉综合征的2型糖尿病患者随机分为两组,胰岛素皮下连续注射法治疗组(CSII组)与胰岛素多次皮下注射法组(MSII组)。两组患者年龄、糖尿病病程、血糖、治疗方式相比无显著性差异,分析低血糖及主要心脏不良事件发生率(室速室颤、心衰、心源性死亡)。结果CSII组的血糖达标时间、低血糖(血糖低于3.0mmol/L)和主要心脏不良事件发生率均低于MSII组。结论胰岛素泵模拟胰岛素的生理分泌模式,能更有效地控制高血糖,并减少糖尿病患者合并急性冠状动脉综合征时主要心脏不良事件发生率。
Objective To compare the therapeutic effects of two different insulin dosage regimens in type 2 diabetic patients with acute coronary syndrome. Methods A total of 168 hospitalized patients with type 2 diabetes mellitus complicated with acute coronary syndrome were randomly divided into two groups: subcutaneous insulin injections group (CSII group) and insulin subcutaneous injection group (MSII group). Two groups of patients age, duration of diabetes, blood glucose, no significant difference in treatment, analysis of hypoglycemia and major cardiac adverse events (ventricular fibrillation, heart failure, cardiac death). Results The blood glucose level, hypoglycemia (blood glucose less than 3.0mmol / L) and major cardiac adverse events in CSII group were lower than those in MSII group. Conclusion The insulin pump simulates the physiological insulin secretion mode, which can control hyperglycemia more effectively and reduce the incidence of major adverse cardiac events in diabetic patients with acute coronary syndrome.