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通过腹腔注射胸腺素α原（ｐｒｏｔｈｙｍｏｓｉｎα，ＰｒｏＴα）或直接用ＰｒｏＴα处理脾Ｔ细胞和腹腔巨噬细胞，检测ＰｒｏＴα对老龄鼠Ｔ细胞增殖活性、Ｔ细胞亚群、ＩＬ１、ＩＬ２及ＴＮＦα活性的影响。实验结果表明：与对照组相比，ＰｒｏＴα在一定剂量上可明显提高老龄鼠的Ｔ细胞增殖活性（ｐ＜０．０１）；明显提高Ｔ细胞亚群中Ｌ３Ｔ＋４细胞数（ｐ＜０．０１）；显著促进ＩＬ２及ＩＬ１和ＴＮＦα的分泌（ｐ＜０．０１）．总之，ＰｒｏＴα对免疫功能状态异常的老龄鼠具有免疫修复活性。
Spleen T cells and peritoneal macrophages were treated with ProTα or proTα directly by intraperitoneal injection of prothymosin α (ProTα), and the effect of ProTα on T cell proliferation, T lymphocyte subsets, IL1, IL2 and TNFα Effect of activity. The experimental results showed that compared with the control group, ProTα could significantly increase the T cell proliferation (p <0.01) and the number of L3T + 4 cells (p <0.01) in the T lymphocyte subsets in a dose- ; Significantly promote IL 2 and IL 1 and TNFα secretion (p <0.01). In summary, ProTα has immunoregulatory activity in old mice with abnormal immune status.