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硝苯啶(Nifedipine)是一种钙通道阻滞剂,选择性地抑制心肌、血管平滑肌上的慢通道,阻滞细胞膜对钙离子的转运功能.近年来随着心肌保护技术的发展,对钙离子在缺血心肌损伤中危害作用的深入了解,许多学者在心外科手术中,对应用硝苯啶加强心肌保护进行了有益的尝试.本文就硝苯啶保护心肌的效果及保护机制综述如下.一、钙离子对心肌再灌注损伤的作用
Nifedipine is a calcium channel blocker that selectively inhibits the slow channels in the myocardium and vascular smooth muscle and blocks the transport of calcium ions to the cell membrane.In recent years, with the development of myocardial protection technology, Ions in the ischemic myocardial injury in the role of harm in-depth understanding of many scholars in cardiac surgery, the use of nifedipine to enhance myocardial protection has made a useful attempt.In this paper, the effect of nifedipine on myocardial protection and protection mechanisms are summarized below. , Calcium ion on myocardial reperfusion injury