Synthesis and biological evaluation of novel thalidomide analogues as potential anticancer drugs

• 出 处: Chinese Chemical Letters
• 发表日期: 2008年08期
• 关键词: thalidomide anticancer hepatoma analogues analogs comparable cytotoxic benzene a

In search of novel anticancer agents,a series of thalidomide analogs(6a-j)were designed and synthesized.Cytotoxicity of these compounds against human hepatoma cells(HepG2)was evaluated by MTT method.Compounds 6d,6h and 6i showed significant cytotoxic activities comparable to or stronger than control 5-fluorouracil.

In a search of novel anticancer agents, a series of thalidomide analogs (6a-j) were designed and synthesized. Cytotoxicity of these compounds against human hepatoma cells (HepG2) was evaluated by MTT method. Compounds 6d, 6h and 6i showed significant cytotoxic activities comparable to or stronger than control 5-fluorouracil.