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乙型肝炎病毒(HBV)是人类慢性肝病最常见的病因。本文分基本概念和临床意义二个方面,介绍HBV三大抗原—抗体系统的相应血清学标志。一、HBsAg和抗HBs (一) 乙型肝炎表面抗原(HBsAg) 1.HBsAg及其主要抗原决定基 HBsAg同另一种病毒编码物质(聚合白蛋白受体)共同组成完整病毒体的外壳,是HBV的中和反应性抗原。HBsAg还能够以与Dane颗粒无关的形式,独立存在于血清之中。这可能是由于:(1) HBsAg的合成和排放速度超过Dane颗粒的装配速度。(2) 整合性感染细胞中,HBsAg基因组得到了独立的表达。 HBsAg有三个相邻的抗原决定基,其中二个由多种不同的基因分别控制。某些细菌具有同HBsAg
Hepatitis B virus (HBV) is the most common cause of chronic liver disease in humans. This article points out the basic concepts and clinical significance of the two aspects, introduces the three HBV antigen - antibody system corresponding serological markers. First, HBsAg and anti-HBs (A) of hepatitis B surface antigen (HBsAg) 1. HBsAg and its main epitope HBsAg together with another viral coding material (albumin albumin receptor) constitute the complete virion shell is Neutralizing reactive antigen for HBV. HBsAg is also present in the serum independently of Dane particles. This may be due to: (1) The rate at which HBsAg is synthesized and discharged exceeds that of Dane particles. (2) The HBsAg genome was independently expressed in the integratively infected cells. HBsAg has three adjacent epitopes, two of which are controlled by a number of different genes. Some bacteria have the same HBsAg