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人体肿瘤除少数几种外,几乎都出现染色体异常,癌症患者染色体异常的频率可达80—100％。不同的癌细胞有不同的染色体异常,同一种癌细胞的染色体异常也往往是各异的。从染色体的数目看,癌细胞一般都是非正倍体,数目变动幅度很大,是高度不平衡核型。在各种癌细胞中,第8号染色体最常出现畸变,其次是1、3、5、7、9、14、17、21和22号染色体。染色体结构
Except for a few kinds of human tumors, there are almost all chromosomal abnormalities. The frequency of chromosomal abnormalities in cancer patients can reach 80-100%. Different cancer cells have different chromosomal abnormalities, the same kind of cancer cells often have different chromosomal abnormalities. From the number of chromosomes, cancer cells are generally non-diploid, a large number of changes, is a highly unbalanced karyotype. Among various cancer cells, chromosome 8 is the most frequently aberrated, followed by chromosomes 1, 3, 5, 7, 9, 14, 17, 21 and 22. Chromosomal structure