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目的 :分析多药耐药相关蛋白 (multidrug resistance associated protein,MRP)、P-糖蛋白 (P- gp)在胃癌组织中表达 ,研究其与胃癌生物学行为及预后的关系。方法 :采用免疫组化法检测 5 3例胃癌组织 MRP、P- gp表达的情况 ,分析其与相关临床资料的关系。结果 :MRP、P- gp表达与临床分期、浸润深度、组织学类型无关。MRP表达与淋巴结转移显著相关 (P <0 .0 1)。 MRP、P- gp表达与 5年生存率无关。结论 :MRP在胃癌组织中的单一表达能一定程度上反映胃癌的生物学行为。 MRP、P- gp均不能较好的反映胃癌的预后
Objective: To analyze the expression of multidrug resistance associated protein (MRP) and P-glycoprotein (P-gp) in gastric cancer tissues and to study their relationship with biological behavior and prognosis of gastric cancer. Methods : The expression of MRP and P-gp in 53 cases of gastric cancer was detected by immunohistochemical method, and the relationship between the expression of MRP and P-gp was analyzed. Results: The expression of MRP and P-gp was not associated with clinical stage, depth of invasion, or histological type. MRP expression was significantly associated with lymph node metastasis (P < 0.01). The expression of MRP and P-gp was not related to the 5-year survival rate. Conclusion : The single expression of MRP in gastric cancer can reflect the biological behavior of gastric cancer to some extent. MRP and P-gp can not reflect the prognosis of gastric cancer