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动脉粥样硬化是一种炎性疾病，多种炎性细胞及炎性因子参与此炎症反应，也参与不稳定性斑块的病理形成过程及随之发生的斑块破裂。平滑肌细胞的增殖、脂质的聚集参与冠状动脉粥样硬化性心脏病（冠心病）病变过程，形成冠状动脉粥样硬化斑块，促使冠状动脉血管管腔狭窄，而斑块的破裂，继发血栓形成，出现不稳定性心绞痛和心肌梗死。脂质核心的大小、斑块纤维帽的厚薄及炎症活动性决定斑块的稳定性，已发现多种炎性因子参与此炎症反应。现就炎性因子及炎性细胞与冠心病斑块稳定性之间的关系进行综述。“,”Atherosclerosis is an inflammatory disease, an inflammatory response involving a variety of inflammatory factors and cells, which also participate the pathogenesis of unstable plaque and subsequent plaque rupture.Proliferation of smooth muscle cells,lipid accumulation participate the pathogenesis of athero-sclerotic coronary artery disease,which narrow the lumen,and the rupture of the atherosclerotic lesion leads to thrombus formation,unstable angina and myocardial infarction.The three determinants of a plaque′s vulnera-bility to rupture are the size of the atheromatous core,the thickness of the fibrous cap covering the core,and inflammation within the cap, and many inflammatory factors have been discovered to be involved in the inflammation.Here is to make a review of the correlation between the inflammatory factors and cells and the stability of coronary heart disease plaques .