论文部分内容阅读
HIV-1感染除导致进行性T 细胞功能缺陷外,还伴有明显的B 细胞功能失调。感染者血循环中含有大量活化的B 细胞,能自发产生主要针对HIV-1的特异性抗体,但对有丝分裂原刺激的应答和抗体同忆反应均降低。这种现象可能与HIV-1诱导的自身免疫损伤及AIDS 患者中B 细胞瘤发病率的升高有关。此外,活化的B 细胞还能产生大量IL-6和TNF-α,从而可能对感染者体内HIV-1的扩散有一定促进作用。为进一步解释这一现象,作者采用外周
HIV-1 infection in addition to lead to progressive T cell dysfunction, but also accompanied by significant B cell dysfunction. Infected persons have a large number of activated B cells in the blood circulation and spontaneously produce specific antibodies against HIV-1 spontaneously, but both mitogen-stimulated responses and antibody-to-antibody responses are reduced. This phenomenon may be related to HIV-1-induced autoimmune damage and AIDS patients with increased incidence of B-cell tumors. In addition, activated B cells can produce large amounts of IL-6 and TNF-α, which may have a certain role in promoting the spread of HIV-1 in infected persons. To further explain this phenomenon, the author uses the periphery