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从１５００名孕妇中筛查出８２名ＨＢｓＡｇ≥１∶６４滴度的阳性携带者的新生儿，按随机、双盲、设安慰剂的原则将研究对象分为疫苗组和对照组（人数比为３∶１）。疫苗组在新生儿出生２４小时内注射第１针，１月、６月龄分别注射第２针、第３针乙肝疫苗，对照组按同样程序注射安慰剂。在第１３年时抗ＨＢｓ阳性率仍高达５９３２％（３５／５９）；对照组１３年来有２３５３％（４／１７）受到自然感染后变为抗ＨＢｓ阳性，疫苗组与对照组有显著性差异（Ｐ＜００５）。疫苗组的抗ＨＢｓ阳性者中，抗ＨＢｓＧＭＴ峰值在第１２个月，Ｓ／Ｎ值为６８８４，到１３年时已下降到１７８２。相当于高峰的１／４，但仍明显高于对照组。除出生时疫苗组与对照组ＨＢｓＡｇ阳性率无明显差异外，疫苗组ＨＢｓＡｇ阳性率一直明显低于对照组，在第１３年时疫苗组和对照组的ＨＢｓＡｇ阳性率分别为１８６４％、４７０６％，有显著性差异（Ｐ＜００５）。
Eighty-five newborns with positive HBsAg ≥1:64 titer were screened out from 1,500 pregnant women. The subjects were divided into vaccine group and control group according to the randomized, double-blind and placebo-based principle 3: 1). In the vaccine group, the first needle was injected within 24 hours of newborn’s birth, the second needle and the third needle of hepatitis B vaccine were injected at January and 6 months, and the control group was injected with placebo. The positive rate of anti-HBs was still as high as 5932% (35/59) at the 13th year. In the control group, 2353% (4/17) were naturally infected and became antiHBs positive in 13 years. The control group had significant difference (P <0 05). Anti-HBs positive in the vaccine group, anti- HBsGMT peak in the 12th month, S / N value of 68 84, 13 years had dropped to 17 82. Equivalent to 1/4 of the peak, but still significantly higher than the control group. The positive rates of HBsAg in the vaccine group were significantly lower than those in the control group except for the positive rate of HBsAg in the vaccine group and the control group at the time of birth. The positive rates of HBsAg in the vaccine group and the control group were 1864% and 47% respectively at the 13th year 06%, there was a significant difference (P <0 05).