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鹅去氧胆酸(CDCA)化学名为3α、7α一二羧基-5β-胆烷酸,主要用于治疗胆固醇型的胆石症临床常用剂型为胶囊剂,由于鹅去氧胆酸是难溶性药物,其吸收受剂型因素的影响。为了保证临床用药有效,本文对乌鲁木齐生化制药厂生产的六个批号胶囊剂进行溶出度测定,为制定药品标准,改进工艺、提高产品质量提供依据。材料样品系乌鲁木齐市生化制药厂生产的鹅去氧胆酸胶囊,共选择六批产品。方法与结果一、溶出度测定 1.测定比较值E
Chenodeoxycholic acid (CDCA) chemical name is 3α, 7α a carboxyl-5β-cholic acid, mainly used for the treatment of cholesterol-based cholelithiasis commonly used forms of capsules, as chenodeoxycholic acid is a poorly soluble drug , Its absorption is affected by the dosage form factor. In order to ensure the effective use of clinical medicine, this article measured the dissolution of six batches of capsules produced by Urumqi Biochemical Pharmaceutical Factory, providing the basis for formulating drug standards, improving technology and improving product quality. Material samples Department of Urumqi Biochemical Pharmaceutical Factory production of chenodeoxycholic acid capsules, a total of six batches of products selected. Methods and Results First, the dissolution determination 1. Determination of comparative value E