【摘 要】
：
Background Pediatric patients are susceptible to lung injury.Acute lung injury (ALI) in children often results in a high mortality.Partial liquid ventilation (P
【机 构】
：
Department of Pediatric Cardiac Surgery Center
论文部分内容阅读
Background Pediatric patients are susceptible to lung injury.Acute lung injury (ALI) in children often results in a high mortality.Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models.This study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of ALI induced by oleic acid (OA).Methods Twelve Chinese immature piglets were induced to develop ALI by oleic acid.The animals were randomly assigned to two groups (n=6): (1) conventional mechanical ventilation (MV) group and (2) PLV with FC-77 (10 ml/kg) group.Results Compared with MV group, PLV group got better cardiopulmonary variables (P ＜0.05).These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen (PaO2), PaO2/FiO2 and partial pressure of arterial carbon dioxide (PaCO2).Partial liquid ventilation reduced IL-1β, IL-6, IL-10 and TN F-α both in plasma and tissue concentrations compared with MV group (P ＜0.05).Conclusions Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.
其他文献
Objective: To investigate the association between KiSS-1 methylation and clinicopathological characteristics of gastric cancer and evaluate the role of peritone
Gastrointestinal tuberculosis(TB) is quite rare,representing only 3% of all extra-pulmonary cases.Blind gut and ileum are the most common gastrointestinal local
Background Most HCC patients with decompensation of liver function lost the chance of surgical and/or interventional treatment. The aim of this study was to eva
Background Estrogen receptor (ER)-negative breast cancer cells are more aggressive than ER-positive cells. Elevated levels of cyclooxygenase-2 (COX-2) and vascu
A microwave-assisted solid phase synthesis for endothelin 1 is presented.Reduced endothelin 1 was synthesized efficiently on Wang resin under microwave irradiat
如果群G的所有真商群都是FO-群,但是群G本身不是FO-群,则称G为外FO-群,本文将给出外FO-群完全的结构描述.
Background A study of prenatal genetic diagnosis for 22q11.2 mierodeletion, which has a wide phenotypic spectrum that involves almost all organs, is rarely repo
Based on established numerical methods and hydrodynamic performance testing facilities, CFD technique are applied to improve the design of the implantable axial
Perivascular epithelioid cell tumor(PEComa) is a rare mesenchymal neoplasia and currently well recognized as a distinct entity with characteristic morphological