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急性冠脉综合征(acute coronary syndrome,ACS)和心房颤动(atrial fibl411ation,Af)是心血管内科的常见多发病,在治疗方面抗凝起着十分重要的作用。肝素和华法林是目前临床广泛使用的抗凝药物。直接凝血酶抑制剂(direct thrombin inhibitors,DTIs)可抑制凝血酶,阻滞凝血酶和纤维蛋白相互作用,并克服肝素／抗凝血酶
Acute coronary syndrome (ACS) and atrial fibrillation (Af) are common and frequently occurring cardiovascular diseases and anticoagulation plays a very important role in the treatment. Heparin and warfarin are currently widely used in clinical anticoagulant drugs. Direct thrombin inhibitors (DTIs) inhibit thrombin, block thrombin and fibrin interactions and overcome heparin / antithrombin