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目的探讨雷公藤多苷片联合泼尼松治疗风湿性多肌痛患者的临床疗效,并对血浆、免疫蛋白进行分析。方法将86例风湿性多肌痛患者随机分为观察组和对照组,每组43例。观察组给予雷公藤多苷片联合泼尼松治疗,对照组仅给予泼尼松片治疗。比较两组患者的临床疗效;并测定患者红细胞沉降率、C反应蛋白、血红蛋白、血小板及血清免疫球蛋白的情况。结果观察组临床有效率为90.70%,对照组临床有效率为58.14%,两组临床疗效相比,差异具有统计学显著性(P<0.05);观察组治疗后与治疗前PMR-AS相比,差异具有统计学意义(P<0.01),对照组治疗后与治疗前PMR-AS相比,差异具有统计学显著性(P<0.05),治疗后,观察组PMR-AS显著低于对照组(P<0.05);治疗后,两组患者的红细胞沉降率、C反应蛋白、血小板、血清免疫球蛋白水平显著低于治疗前(P<0.05),血红蛋白水平显著高于治疗前(P<0.05);且治疗后,观察组患者的各项检测指标水平与对照组相比,差异具有统计学意义(P<0.01)。两组不良反应发生率相比,差异具有统计学意义(P<0.05)。结论雷公藤多苷片联合泼尼松治疗风湿性多肌痛的疗效优于单独给予泼尼松,对患者血浆红细胞沉降率、血清免疫球蛋白、C反应蛋白、血小板有降低的作用,对血红蛋白有升高的作用。
Objective To investigate the clinical efficacy of Tripterygium wilfordii polyphosphate tablets combined with prednisone in the treatment of rheumatic polymyalgia and to analyze the plasma and immune proteins. Methods 86 cases of rheumatic polymyalgia patients were randomly divided into observation group and control group, 43 cases in each group. The observation group received tripterygium glycosides tablets combined with prednisone, while the control group received only prednisone tablets. The clinical efficacy of the two groups was compared. The erythrocyte sedimentation rate, C-reactive protein, hemoglobin, platelet and serum immunoglobulin in patients were also measured. Results The clinical effective rate was 90.70% in the observation group and 58.14% in the control group. The difference between the two groups was statistically significant (P <0.05). Compared with the pre-treatment PMR-AS , The difference was statistically significant (P <0.01), the difference between the control group and the pre-treatment PMR-AS was statistically significant (P <0.05), after treatment, the observation group PMR-AS was significantly lower than the control group (P <0.05). After treatment, the erythrocyte sedimentation rate, C-reactive protein, platelet and serum immunoglobulin in both groups were significantly lower than those before treatment (P <0.05) and hemoglobin levels were significantly higher than those before treatment ); And after treatment, the observation group patients with various test indicators compared with the control group, the difference was statistically significant (P <0.01). There was a significant difference between the two groups in the incidence of adverse reactions (P <0.05). Conclusions The effect of tripterygium wilfordii tablet combined with prednisone on rheumatic polymyalgia is better than that of prednisone alone. It has the effect of reducing erythrocyte sedimentation rate, serum immunoglobulin, C-reactive protein and platelet in patients with hemoglobin There is an increase in the role.