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脑卒中是导致长期残疾的主要原因,世界卫生组织2010年数据显示脑卒中每年造成大约6百万人死亡,是全世界导致死亡的第二大原因。其中缺血性脑卒中通常占80%,多归因于栓塞或血栓形成引起的动脉阻塞。缺血性脑卒中具有复杂的病理生理过程,其中炎症小体发挥了重要的作用,类核苷酸结合寡聚化域受体1(NLRP1)和3(NLRP3)作为炎症小体重要的家族成员,在缺血性脑卒中的发生、发展中占据重要的位置。
Stroke is the leading cause of long-term disability, with WHO’s 2010 data showing that stroke causes about 6 million deaths annually, the second leading cause of death worldwide. Including ischemic stroke is usually 80%, mostly due to embolism or thrombosis caused by arterial obstruction. Ischemic stroke has a complex pathophysiological process in which the inflammasome plays an important role. Nucleotide-binding oligomerization domain receptor 1 (NLRP1) and 3 (NLRP3) are important family members of the inflammasome , Occupy an important position in the occurrence and development of ischemic stroke.