The HMGB1 signaling pathway activates the inflammatory response in Schwann cells

• 作 者: Li-li Man Fan Liu Ying-jie Wan
• 机 构: KeyLaboratoryofNeuroregeneration,DepartmentofOncology,DepartmentofPediatrics,MedicalCollege
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2015年10期
• 关键词: HMGB1 信号转导通路 雪旺细胞 炎症反应 激活 Toll样受体 外周神经损伤 晚期糖基化终产物 nerve regeneration peripheral
• 基金项目: supported by the National Natural Science Foundation of China,No.31471011, a grant from the National Program on Key Basic Research Project of China（973 Program）,No.2014CB542202, the Natural Science Fo

Schwann cells are not only myelinating cells, but also function as immune cells and express numerous innate pattern recognition receptors, including the Toll-like receptors. Injury to peripheral nerves activates an inflammatory response in Schwann cells.