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目的：应用组织化学染色对６１例肝活检标本进行研究，观察胶原纤维在慢性肝病组织中的分布，研究由慢性肝炎到肝硬化肝纤维化的形成过程。方法：应用ＶＧ染色显示慢性肝病组织中的胶原纤维，光镜观察。结果：胶原纤维染成粉红色，形成间隔分割肝实质。结论：ＶＧ染色对慢性肝病有诊断学意义。肝实质内的纤维组织可能来源于成纤维细胞和贮脂细胞。
OBJECTIVE: To study the distribution of collagen fibers in chronic liver disease (HCC) by using histochemical staining and to study the formation of liver fibrosis from chronic hepatitis to cirrhosis. Methods: Collagen fibers in chronic liver disease were observed by VG staining. RESULTS: Collagen fibers dyed pink to form compartmentalised hepatic parenchyma. Conclusion: VG staining has diagnostic significance for chronic liver disease. Fibrous tissue within the liver parenchyma may originate from fibroblasts and fat-storing cells.