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目的总结分析利用观察米非司酮治疗围绝经期功能性子宫出血的疗效。方法我院接收的80例围绝经期功能性子宫出血患者作为临床观察对象。将所有病患随机均分为观察组和对照组。观察组给予米非司酮口服疗法,对照组进行安宫黄体酮疗法。观察对比两组病患子宫内膜厚度、子宫大小、血清激素含量变化以及不良反应情况。结果观察组病患子宫横径是(5.9±1.4)cm;前后径是(4.7±1.3)cm,子宫体积是(53.4±3.3)cm3;子宫内膜厚度是(2.9±0.5)cm;促卵泡生成素是(8.5±2.4)U/L,黄体生成素是(6.5±1.6)U/L;孕激素是(1.8±1.6)nmol/L;雌二醇是(109±1.6)pmol/L,不良反应的发生率是7.5%,观察组整体治疗效果明显优于对照组(P<0.05)。结论对围绝经期功能性子宫出血采用米非司酮口服疗法,效果显著,不良反应发生率低,值得临床考虑应用。
Objective To summarize and analyze the efficacy of mifepristone in treating peri-menopausal dysfunctional uterine bleeding. Methods Eighty patients with functional uterine bleeding during perimenopausal period were selected as clinical observation subjects. All patients were randomly divided into observation group and control group. The observation group was given mifepristone oral therapy, and the control group was given progestin progesterone therapy. The levels of endometrial thickness, uterine size, serum hormone levels and adverse reactions in the two groups were observed and compared. Results The transverse diameter of the uterus in the observation group was (5.9 ± 1.4) cm; the anteroposterior diameter was (4.7 ± 1.3) cm and the uterus volume was (53.4 ± 3.3) cm3; the thickness of the endometrium was (2.9 ± 0.5) cm; (8.5 ± 2.4) U / L, (6.5 ± 1.6) U / L for progesterone, (1.8 ± 1.6) nmol / L for progesterone and (109 ± 1.6) pmol / The incidence of adverse reactions was 7.5%, the observation group overall treatment effect was significantly better than the control group (P <0.05). Conclusion Mifepristone oral therapy for functional uterine bleeding during peri-menopausal period has a significant effect and a low incidence of adverse reactions, which deserves clinical application.