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目的:对载药聚乙烯醇(PVA)超细纤维膜的制备及体外释药行为进行研究。方法:利用静电纺丝技术制备了相对质量分数分别为10%,20%,30%,40%的硒化环糊精(2-SeCD)/聚乙烯醇(PVA)超细纤维,通过红外光谱(FT-IR)以及扫描电镜照片(SEM)对不同质量分数的载药纤维进行了结构和性能的表征,紫外-可见光分光度计测试了载药超细纤维在人工肠液,人工胃液的体外释药行为。结果:随着2-SeCD含量的增加,载药纤维直径变大,累计释药曲线增长趋于缓慢,同一体积分数的载药超细纤维,在人工肠液中的累计释药率高于人工胃液的释药率。结论:载药超细纤维具有较好的缓释效果,有一定的靶向药位。
Objective: To study the preparation of drug-loaded polyvinyl alcohol (PVA) microfiber membrane and its in vitro release behavior. Methods: Ultrafine selenated cyclodextrin (2-SeCD) / polyvinyl alcohol (PVA) fibers with relative mass fractions of 10%, 20%, 30% and 40% were prepared by electrospinning. (FT-IR) and scanning electron microscopy (SEM) were used to characterize the structure and properties of drug-loaded fibers with different mass fractions. Ultraviolet-visible spectrophotometer was used to test the in vitro release of the loaded superfine fibers in artificial intestinal juice and artificial gastric juice Drug behavior. Results: With the increase of 2-SeCD content, the diameter of drug-loaded fibers became larger and the cumulative drug release curve tended to be slower. The cumulative release rate of drug-loaded microfibers with the same volume fraction in artificial intestinal juice was higher than that of artificial gastric juice The release rate. Conclusion: Drug-loaded microfiber has better sustained-release effect, and has certain targeting potential.