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目的探讨肺表面活性物质(PS)是否具有预防早产儿呼吸窘迫综合征(NRDS)的临床作用。方法对2001年1月至2005年12月浙江省台州市第一人民医院新生儿科收治的114例高危早产儿分成两组,预防组52例,为家庭条件允许应用PS者;对照组62例为同期住院未应用PS者。预防组用药前及用药后6 h分别采动脉血进行血气分析。对照组在入院时及综合处理后6 h也分别采动脉血进行血气分析。两组患儿入院后24 h内均拍胸片了解肺部情况,对两组进行比较。结果预防组可有效减少NRDS的发病率及减轻病情,两组pH、PaO2、PaCO2值比较差异有统计学意义(P<0.05)。两组并发NRDS情况比较差异有统计学意义(P<0.05)。结论预防性应用肺表面活性物质可有效减少NRDS的发病率及减轻病情。
Objective To investigate whether pulmonary surfactant (PS) has the preventive effect on respiratory distress syndrome (NRDS) in preterm infants. Methods A total of 114 high risk preterm infants admitted to the First People ’s Hospital of Taizhou, Zhejiang Province from January 2001 to December 2005 were divided into two groups. The prevention group was divided into two groups, the PS group was allowed for family condition. The control group, 62 cases were Over the same period did not apply PS hospital. Prevention group before treatment and 6 h after treatment were taken arterial blood gas analysis. Control group at admission and 6 h after the integrated treatment were also taken blood gas analysis of arterial blood. Two groups of children within 24 h after admission were taken chest radiography to understand the situation of the lungs, the two groups were compared. Results The prevention group could effectively reduce the incidence of NRDS and alleviate the disease. There was significant difference between the two groups in pH, PaO2 and PaCO2 (P <0.05). There were significant differences between the two groups in the incidence of NRDS (P <0.05). Conclusion Preventive use of pulmonary surfactant can effectively reduce the incidence of NRDS and alleviate the disease.