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目的通过对金华市范围内新发现的178例HIV感染者进行首次CD4~+T淋巴细胞检测,了解其免疫状态及疾病进展情况,为HIV/AIDS防治工作提供科学依据。方法采用流式细胞术对采集的178份抗凝全血样本进行CD4~+T和CD8~+T淋巴细胞绝对值检测,并计算CD4~+/CD8~+比值。结果 178例HIV感染者首次CD4~+T淋巴细胞计数均值为(376.06±212.37)个/μl,其中≤200个/μl的占21.9%,201个/μl~350个/μl的占27.5%,351个/μl~500个/μl的占28.1%,>500个/μl的占22.5%。CD4~+/CD8~+比值平均为0.31±0.19,CD4~+/CD8~+比值>1的仅2例,CD4~+/CD8~+比值<0.5的占87.6%。不同性别、不同年龄、不同感染途径CD4~+T淋巴细胞均数和CD4~+/CD8~+比值差异无统计学意义(P>0.05)。结论金华市可随访到的77.5%的HIV感染者符合治疗标准,需要监测疾病过程并及时对其进行抗病毒治疗。
Objective To detect the first immunization of CD4 + T lymphocytes in 178 cases of HIV-infected persons in Jinhua City, and to find out the status of their immune status and disease progression so as to provide a scientific basis for prevention and control of HIV / AIDS. Methods The absolute CD4 ~ + T and CD8 ~ + T lymphocytes were detected by flow cytometry in 178 anticoagulated whole blood samples and the ratio of CD4 ~ + / CD8 ~ + was calculated. Results The mean CD4 ~ + T lymphocyte count of 178 HIV-infected patients was (376.06 ± 212.37) / μl for the first time, of which 21.2% were ≤200 / μl, 27.5% were from 201 / μl to 350 / μl, From 351 / μl to 500 / μl accounted for 28.1% and> 500 / μl accounted for 22.5%. The average ratio of CD4 ~ + / CD8 ~ + was 0.31 ± 0.19, only 2 cases had CD4 ~ + / CD8 ~ + ratio> 1 and 87.6% had CD4 ~ + / CD8 ~ + ratio <0.5. There was no significant difference in mean CD4 ~ + T lymphocyte number and CD4 ~ + / CD8 ~ + ratio between different sexes, different ages and different routes of infection (P> 0.05). Conclusion 77.5% of HIV-infected patients who can follow up in Jinhua City meet the treatment standards and need to monitor the disease process and conduct anti-virus treatment in time.