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目的了解贵阳市甲型副伤寒沙门菌的耐药状况及其变迁,为临床用药、应急药品储备及预防服药等提供依据。方法采用WHO推荐的改良K-B法,对贵阳市2000-2007年部分甲型副伤寒沙门菌进行药敏实验。结果贵阳市甲型副伤寒沙门菌对多种抗菌素耐药,合计耐药率93.2%,其中,萘啶酸耐药率最高89.0%,其次是头孢噻吩7.5%,复方新诺明、头孢噻肟和氯霉素的耐药率分别为2.7%、2.1%和1.4%。头孢噻吩的耐药率呈上升的趋势。双耐药、三重耐药及四重耐药菌株主要采集于甲型副伤寒高流行县区。结论贵阳市甲型副伤寒沙门菌存在多重耐药性,可能是其流行原因之一;耐药性日趋严重,提示药敏监测对该地区甲型副伤寒流行控制有重要意义。
Objective To understand the drug resistance status and its changes of Salmonella paratyphi A in Guiyang and to provide basis for clinical medication, emergency drug storage and preventive medication. Methods The modified K-B method recommended by WHO was used to test the susceptibility of some Salmonella typhi in 2000-2007 in Guiyang. Results Salmonella paratyphi A was resistant to a wide range of antibiotics, with a total resistance rate of 93.2%, of which nalidixic acid resistance was the highest (89.0%), followed by cefalotin 7.5%, cotrimoxazole, cefotaxime And chloramphenicol resistance rates were 2.7%, 2.1% and 1.4% respectively. Cefalotin resistance rates showed an upward trend. Dual drug resistance, triple drug resistance and quadruple drug resistance strains were collected in the high prevalence of Paratyphoid A county. Conclusion The multi-drug resistance of Salmonella paratyphi A in Guiyang may be one of the causes of the epidemic. The drug resistance is becoming more and more serious, which indicates that the drug susceptibility monitoring is of great significance to the epidemic control of Paratyphoid A in this area.