论文部分内容阅读
目的观察布林佐胺联合噻吗心安治疗开角型青光眼的临床疗效和安全性。方法将30例(52只眼)开角型青光眼患者随机分为治疗组和对照组。治疗组采用1%布林佐胺联合0.25%噻吗心安滴眼液治疗,对照组采用0.25%噻吗心安滴眼液治疗,比较2种治疗方法的降眼压作用及不良反应。结果 2组治疗后2,6,12周眼压均有所下降,与治疗前比较有统计学意义(P<0.05),且治疗组与对照组比较有统计学意义(P<0.05);治疗后治疗组无血压变化和心率抑制,对照组无血压变化,但出现心率抑制现象。2组均未见明显不良反应。结论布林佐胺联合噻吗心安治疗开角型青光眼具有明显的降眼压作用,且无明显不良反应,值得临床推广应用。
Objective To observe the clinical efficacy and safety of brinzolamide combined with timolol in the treatment of open-angle glaucoma. Methods Thirty patients (52 eyes) with open-angle glaucoma were randomly divided into treatment group and control group. The treatment group was treated with 1% Brinzolamide combined with 0.25% timolol eye drops. The control group was treated with 0.25% timolol eye drops. The intraocular pressure (IOP) and adverse reactions were compared between the two treatment methods. Results The intraocular pressure (IOP) of the 2 groups decreased at 2, 6, 12 weeks after treatment, which were statistically significant compared with those before treatment (P <0.05), and the treatment group and the control group were statistically significant (P <0.05) After treatment, there was no change of blood pressure and heart rate, while no change of blood pressure in the control group, but the phenomenon of heart rate depression appeared. No obvious adverse reactions were found in both groups. Conclusion Brinzolamide combined with timolol in the treatment of open-angle glaucoma has a significant reduction of intraocular pressure, and no significant adverse reactions, is worthy of clinical application.