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目的探究胎膜早破新生儿血清中C反应蛋白及降钙素原水平对新生儿细菌感染的诊断价值。方法选取我院2014年2月~2015年2月单胎分娩的胎膜早破足月新生儿共136例,根据有无细菌感染征象分为感染组(N=67)与对照组(N=69),比较两组新生儿出生后1d、3d血清CRP、PCT含量,及感染组新生儿CRP与PCT灵敏度与特异度。结果新生儿出生后1d,感染组新生儿血清CRP及PCT明显高于对照组,P<0.05。新生儿出生后3d,感染组PCT明显高于对照组,P<0.05,两组新生儿CRP无明显统计学差异,P>0.05。感染组新生儿出生后1d、3d PCT检测灵敏度与特异度均高于CRP,P<0.05。结论 CRP与PCT在胎膜早破新生儿细菌感染早期诊断中均有一定价值,但PCT敏感性与特异性高于CRP,可指导临床诊断。
Objective To investigate the diagnostic value of serum C-reactive protein and procalcitonin in neonates with premature rupture of membranes in the diagnosis of neonatal bacterial infection. Methods A total of 136 newborn infants with premature rupture of membranes were selected from February 2014 to February 2015 in our hospital. According to the presence or absence of bacterial infection, they were divided into infection group (N = 67) and control group (N = 69). The levels of serum CRP, PCT, and the sensitivity and specificity of CRP and PCT in neonates were compared between two groups at 1 day and 3 days after birth. Results The level of CRP and PCT in newborn infants was significantly higher than that in control one day after birth (P <0.05). The newborn’s postnatal 3d, PCT infection group was significantly higher than the control group, P <0.05, CRP no significant difference between the two groups, P> 0.05. The sensitivity and specificity of 3d PCT examination were higher than those of CRP at 1 day after birth in neonates with infection, P <0.05. Conclusion Both CRP and PCT have some value in the early diagnosis of bacterial infection in premature rupture of membranes. However, the sensitivity and specificity of PCT are higher than that of CRP, which can guide the clinical diagnosis.