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有污染物二氯二三氯乙烷(DDT)、三丁锡(TBT)和2,3,7,8-四氯二并二噁英(TCDD)因对水生生态系统的害以对人体健康造成的重伤害而受到重视.实验以生物原生动物嗜热四虫为究对象,利用microarray技筛选了在上3种污染物下分别露24h后差异表达2倍以上的因,并在gene ontology功能注释的础上,通过富分析考察了这些因涉的主要功能,其中许多功能和多细胞生物中的道相一致.随后,以TCDD中富功能注释的因为核心,通过CLR算法构建了TCDD相关因的相互作用网络,依照功能将其划分为2个亚网络,并在此础上推测了TCDD在四虫中的作用制型.结果显,四虫有成为在因组水平究毒物作用制的单细胞生物型的大潜力.
Some contaminants, such as DDT, TBT and 2,3,7,8-tetrachlorodibenzodioxin (TCDD), are harmful to aquatic ecosystems due to human health Caused by serious injury.According to the four protozoan protozoan thermophiles, microarray was used to screen genes that were more than 2-fold differentially expressed in the top three pollutants for 24h, respectively, Based on these annotations, many of these major functions involved were examined by the analysis of abundance, many of which are consistent with those in multicellular organisms. Subsequently, TCDD-related causes were constructed by the CLR algorithm for the core of well-annotated TCDD Interaction network, according to the function of its subdivision into two sub-networks, and on this basis speculated that TCDD role in the four insects model results show that four insects have become due to the level of toxic effects of single-cell system Great potential for biotypes.