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目的探讨喀什地区维吾尔族(维族)妇女血脂水平与子宫颈病变及其病变程度的相关性。方法 79例子宫颈病变患者为观察组,其中CIN 1级57例,CIN 2级14例,CIN 3级5例,宫颈癌3例;无子宫颈病变者158例为对照组。检测2组血脂水平,采用logistic回归分析血脂水平对罹患子宫颈病变的相对危险度,采用Spearman相关分析法分析子宫颈病变程度与血脂水平间相关性。结果观察组总胆固醇(total cholesterol,TC)((4.29±0.90)mmol/L)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)((2.43±0.70)mmol/L)和三酰甘油(triacylglycerol,TG)((1.17±0.80)mmol/L)水平均高于对照组((3.35±1.10)、(1.95±0.80)和(0.87±0.50)mmol/L)(P<0.05),高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平与对照组比较差异无统计学意义(P>0.05);高TG水平(OR=5.529,95%CI:1.481~20.647,P=0.011)和低HDL-C水平(OR=0.420,95%CI:0.224~0.788,P=0.007)为患子宫颈疾病的危险因素;TC和LDL-C水平与子宫颈病变程度呈正相关(r=0.314,P=0.005;r=0.398,P=0.000)。结论血清高TG和低HDL-C水平可能增加患子宫颈病变的风险;子宫颈病变患者TC和LDL-C水平升高可能与病变进展有关。
Objective To investigate the relationship between the level of serum lipids and the severity of cervical lesions among Uighur (Uighur) women in Kashgar. Methods A total of 79 cases of cervical lesions were observed. Among them, 57 cases were grade CIN 1, 14 cases were CIN 2 grade, 5 cases were grade CIN 3, 3 cases were cervical cancer, and 158 cases without cervical lesion were control group. The serum lipids were measured in two groups. The relative risk of cervical lesions was analyzed by logistic regression analysis. The correlation between cervical lesions and serum lipids was analyzed by Spearman correlation analysis. Results The levels of total cholesterol (TC) (4.29 ± 0.90 mmol / L), low density lipoprotein-cholesterol (LDL-C) The level of triacylglycerol (TG) (1.17 ± 0.80) mmol / L was higher than that of the control group (3.35 ± 1.10, 1.95 ± 0.80 and 0.87 ± 0.50 mmol / L, P <0.05) , High HDL-C levels were not significantly different from those of the control group (P> 0.05). High TG levels (OR = 5.529, 95% CI: 1.481 ~ 20.647, P = 0.011) and low HDL-C levels (OR = 0.420, 95% CI: 0.224-0.788, P = 0.007) were risk factors for cervical disease. The levels of TC and LDL-C were positively correlated with the severity of cervical lesions (r = 0.314, P = 0.005; r = 0.398, P = 0.000). Conclusion Serum high TG and low HDL-C levels may increase the risk of cervical lesions; elevated levels of TC and LDL-C in patients with cervical lesions may be related to the progress of the disease.