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【目的】初步探讨儿童后期哮喘患病与早期羅患呼吸道感染性疾病之间的关系。【方法】共317例哮喘儿童纳入研究,317例非喘息性疾病患儿作为对照。采用向家长书面问卷调查方法询问各组婴儿围产期因素、家族史及既往呼吸道感染性疾病等资料进行综合调查。采用后退法进行哮喘患病危险因素的多因素配比条件Logistic回归分析。【结果】在校正了其他与儿童哮喘发生发展密切相关的因素后,既往上/下呼吸道感染次数以及下呼吸道初发年龄与儿童期哮喘的发病存在密切相关;上呼吸道感染和下呼吸道感染的发作次数以及下呼吸道感染的初次发作年龄均与哮喘中度、重度发作关系密切。上呼吸道感染初次发作年龄与儿童哮喘发作以及病情程度均无显著关系。【结论】本地区儿童早期呼吸道感染与儿童四岁左右哮喘的发生发展以及发作程度密切相关。
【Objective】 To investigate the relationship between early stage childhood asthma and respiratory diseases in early stage. 【Methods】 A total of 317 asthmatic children were enrolled in the study, and 317 non-wheezing children were used as controls. A written survey of parents asked the method of perinatal infants in each group factors, family history and previous respiratory tract infection and other data for a comprehensive survey. Logistic regression analysis was used to evaluate the risk factors for asthma by multi - factor matching. 【Results】 After adjusting for other factors closely related to the development and progression of childhood asthma, the number of previous upper / lower respiratory tract infections and the initial age of lower respiratory tract were closely related to the incidence of childhood asthma. The incidence of upper respiratory tract infection and lower respiratory tract infection The number of times and the initial seizure age of lower respiratory tract infection were all closely related to the moderate and severe asthma attacks. There was no significant relationship between the age of onset of upper respiratory tract infection and the onset of asthma in children and the severity of illness. 【Conclusions】 Early childhood respiratory infection in children in this area is closely related to the occurrence and development of asthma in children around the age of 4 years.