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以取代苯、丁烯二酸酐、邻氨基(对氯邻氨基)苯酚为原料,合成了一系列2-酯基-1,5-苯并氧氮杂衍生物,其结构通过IR,1H NMR,MS(HRMS)及元素分析进行表征.同时,确定了一个主要副产物2-苯甲酰甲基-2H-1,4-苯并噁嗪-3(4H)-酮(6h’)的结构,提出了其可能的生成机理.研究还表明,中间体4-芳基-4-氧代-2-丁烯酸酯(4)在对甲基苯磺酸为催化剂、DMF作溶剂、回流温度下反应时主要生成目标产物2-酯基-1,5-苯并氧氮杂6,而在冰醋酸为催化剂、甲醇作溶剂、回流温度下反应时则主要生成副产物6h’.
A series of 2-ester-1,5-benzoxazepine derivatives have been synthesized by substituting benzene, maleic anhydride and o-amino (p-chloro-o-amino) phenol. The structures were characterized by IR, , MS (HRMS) and elemental analysis, and the structure of 2-phenacyl-2H-1,4-benzoxazin-3 (4H) -one (6h ’ , And its possible mechanism of formation was also proposed.The study also showed that the intermediate 4-aryl-4-oxo-2-butenoate (4) in p-toluenesulfonic acid as a catalyst, DMF as a solvent, reflux temperature Under the reaction, the target product 2-ester-1,5-benzoxazepine 6 is mainly formed, while in the reaction of glacial acetic acid as the catalyst and methanol as the solvent, the by-product 6h ’is mainly generated when the reaction is carried out under the refluxing temperature.