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Fc受体和iC3b受体参与吞噬性细胞的多种生物学功能。本文着重研究人单核细胞在体外用IgG多聚体和单体IgG处理后其IgG Fc段受体(FcR)及iC3b受体(CR3)的表达以及对细胞功能的影响。文中报告人单核细胞与可溶性多聚IgG相互作用后引起Fc受体的长期向下调节。并认为IgG对Fc受体的调节作用主要取决于其存在形式。如果结合至培养皿的表面,单体
Fc receptors and iC3b receptors are involved in a variety of biological functions of phagocytic cells. This article focuses on the expression of human Fc-receptor (FcR) and iC3b receptor (CR3) and their effect on cell function after in vitro treatment of human monocytes with IgG multimers and monomeric IgG. The authors report that monocytes interact with soluble poly-IgG to induce long-term downregulation of Fc receptors. And that IgG regulation of Fc receptors mainly depends on its existing form. Monomer if bound to the surface of the Petri dish