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核因子-κB(NF-κB)是一种广泛存在于体内细胞的核转录因子,NF-κB可因一些细胞因子、氧化剂、蛋白激酶、脂多糖等的刺激而被激活,调节细胞因子、趋化因子、生长因子、粘附分子、免疫受体基因和转录因子等多种物质的表达。因此,在细胞分化、免疫反应、炎症反应、细胞凋亡、肿瘤生长及血液性疾病等的病理生理过程中发挥重要作用。在肝脏炎症、纤维化及肝细胞再生、凋亡等病理生理过程中都伴有NF-κB的活化,NF-κB参与调控肝细胞的凋亡和增殖,并调节局部各种介质释放引起的炎症反应,同时促发KC产生各种炎性因子,扩大肝脏炎症,最终使肝星状细胞活化,产生大量胶原纤维,形成肝纤维化。
Nuclear factor-κB (NF-κB) is a nuclear transcription factor widely present in the body. NF-κB can be activated by some cytokines, oxidants, protein kinases and lipopolysaccharides to regulate cytokines, Factor, growth factor, adhesion molecules, immune receptor genes and transcription factors and other substances. Therefore, it plays an important role in the pathophysiological processes such as cell differentiation, immune response, inflammatory response, apoptosis, tumor growth and hematological diseases. In liver inflammation, fibrosis and hepatocyte regeneration, apoptosis and other pathophysiological processes are associated with activation of NF-κB, NF-κB is involved in the regulation of apoptosis and proliferation of hepatocytes, and regulate the local release of various mediators of inflammation Reaction, and promote KC produce a variety of inflammatory cytokines, expanding liver inflammation, and ultimately activation of hepatic stellate cells, resulting in a large number of collagen fibers, the formation of liver fibrosis.