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目的探讨老年T2DM患者血浆胱抑素C(Cys-C)水平变化与糖尿病慢性肾脏疾病(CKD)的相关性。方法选取老年T2DM患者(T2DM组)100例和健康体检者(NC)35名,根据UAlb/Cr结果将T2DM组分为<30mg/24h亚组32例,30~299mg/24h亚组35例和>300mg/24h亚组33例。测定各组血浆Cys-C水平和Ccr。结果T2DM组和CKD各组血浆Cys-C水平均高于NC组(P<0.05)。CKD患者血浆Cys-C水平与糖尿病病程、UAlb/Cr呈正相关(r=0.368、0.463,P<0.05),与Ccr呈负相关(r=-0.802,P<0.05)。结论血浆Cys-C水平与老年T2DM患者肾功能损伤密切相关,可有效的评估CKD患者的肾功能。
Objective To investigate the relationship between the changes of plasma cystatin C (Cys-C) and chronic kidney disease (CKD) in elderly patients with type 2 diabetes. Methods 100 elderly patients with T2DM (T2DM group) and 35 healthy subjects (NC) were enrolled in this study. According to the results of UAlb / Cr, 32 patients with T2DM were divided into 30 subgroups of <30mg / 24h and 35 subgroups of 30 to 299mg / > 300mg / 24h subgroup of 33 cases. Plasma Cys-C level and Ccr were measured in each group. Results Plasma Cys-C levels in T2DM and CKD groups were significantly higher than those in NC group (P <0.05). The level of Cys-C in CKD patients was positively correlated with duration of diabetes and UAlb / Cr (r = 0.368,0.463, P <0.05), but negatively correlated with Ccr (r = -0.802, P <0.05). Conclusions Plasma Cys-C levels are closely related to renal function impairment in elderly patients with T2DM, which can effectively evaluate renal function in patients with CKD.