论文部分内容阅读
Background: Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease. Objective: To inves tigate the hypothesis that relative elevations in leukocyte count in a stroke- free population predict future ischemic stroke (IS). Methods: A populationbased prospective cohort study was performed in a multiethnic urban population. Stroke - free community participants were identified by random- digit dialing. Leukoc yte levels were measured at enrollment, and participants were followed annually for IS, myocardial infarction (MI), and cause- specific mortality. Cox proporti onal hazards regression models were used to calculate hazard ratios (HRs) and 95 % CIs for IS, MI, and vascular death after adjustment for medical, behavioral, and socioeconomic factors. Results: Among 3,103 stroke- free community partici pants (mean age 69.2 ± 10.3 years) with baseline leukocyte levels measured, med ian follow- up was 5.2 years. After adjusting for stroke risk factors, each SD in leukocyte count (1.8 × 109 cells/L) was associated with an increased risk of IS (HR 1.22, 95% CI 1.05 to 1.42), and IS, MI, or vascular death (HR 1.13, 95 % CI 1.02 to 1.26). Compared with those in the lowest quartile of leukocyte co unt, those in the highest had an increased risk of IS (adjusted HR 1.75, 95% C I 1.08 to 2.82). The effect on atherosclerotic and cardioembolic stroke was grea ter than in other stroke subtypes. Conclusion: Relative elevations in leukocyte count are independently associated with an increased risk of future ischemic str oke and other cardiovascular events.
Background: Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease. Objective: To inves tigate the hypothesis that relative elevations in leukocyte count in a stroke- free population predict future ischemic cardiac (IS). Methods: A populationbased prospective cohort study was performed in a multiethnic urban population. Stroke - free community participants identified by random-digit dialing. Leukoc yte levels were measured at enrollment, and participants were followed annually for IS, myocardial infarction (MI), and cause - specific mortality. Cox proporti onal hazards regression models were used to calculate hazard ratios (HRs) and 95% CIs for IS, MI, and vascular death after adjustment for medical, behavioral, and socioeconomic factors. Results: Among 3,103 stroke-free community partici pants (mean age 69.2 ± 10.3 years) with baseline leukocyte levels, med ian follow-up was 5.2 years. After adjusti ng for stroke risk factors, each SD in leukocyte count (1.8 × 109 cells / L) was associated with an increased risk of IS (HR 1.22, 95% CI 1.05 to 1.42), and IS, MI, or vascular death , 95% CI 1.02 to 1.26). Compared to those in the lowest quartile of leukocyte co unt, those in the highest had an increased risk of IS (adjusted HR 1.75, 95% CI 1.08 to 2.82). The effect on atherosclerotic and cardioembolic stroke was grea ter than in other stroke subtypes. Conclusion: Relative elevations in leukocyte count are independently associated with an increased risk of future ischemic str oke and other cardiovascular events.