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自20世纪80年代,研究提示摄入富含蔬菜和水果的膳食与恶性肿瘤的发生和死亡有一定的关系,随后人们开始探索服用额外的膳食补充剂是否会降低全肿瘤发生和死亡的风险。虽然动物实验发现了可喜的结果,但膳食补充剂的作用在人群队列研究和随机对照干预试验中的结果并不如预期。本文围绕膳食补充剂,尤其是抗氧化补充剂与全肿瘤死亡风险关系的流行病学研究进展进行综述,以期为中国居民长期服用膳食补充剂提供依据。
Since the 1980s, studies have suggested that the intake of vegetables and fruits rich in diet and cancer incidence and death have a certain relationship, then people began to explore whether taking additional dietary supplements will reduce the risk of total tumor occurrence and death. Although good results have been found in animal experiments, the effects of dietary supplements on population cohort and randomized controlled trials have not been as expected. This article reviews the progress of epidemiological studies on the relationship between dietary supplements, especially antioxidant supplements and the risk of total tumor death, in order to provide the basis for Chinese residents to take dietary supplements for a long time.