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粉末混合是生产片剂和胶囊的重要步骤.Lacey早把二元干燥粉末系统视为其在三维体系的统计学随机化,奠定了粉末混合理论基础.这种随机混合法要求所有粒子不能相互作用,且物理性质(除颜色外)相同.但是,Travers等首先描述了低密度,非常细的药物粉末吸附到宿主结晶上,防止因粒子大小不同引起的分离,Hersey称之为“有序混合法”.有序混合物的均匀度经常高于相应理论方差最小的随机混合物,即粘附粉末混合物比最好的随机混合物更有秩序.很显然,任何粒子依各种力(色散力、万有引力)的相互作用,没有完全非作用的混合物.真实粉末体系中,游离的与结合的粒子处于动态,因此,两个极端的主要区别是非粘附与粘附.
Powder mixing is an important step in the production of tablets and capsules.Lacey earlier considered the binary dry powder system as a statistical randomization in a three-dimensional system, laying the foundations for the theory of powder mixing, which requires that all particles do not interact , And the physical properties are the same (except for color), but Travers et al. First described the adsorption of low density, very fine drug powders onto host crystals to prevent separation due to particle size differences, which Hersey calls “ordered mixing Method. ”The orderly mixture is often more homogenous than the random mixture with the lowest theoretical variance, ie, the adherent powder mixture is more orderly than the best random mixture.It is clear that any particle that depends on various forces (dispersion, gravitation ), There is no complete non-action mixture.In the real powder system, the free and bound particles are dynamic, so the main difference between the two extremes is non-adhesion and adhesion.